Gene for von Recklinghausen Neurofibromatosis Is in the Pericentromeric Region of Chromosome 17
- 29 May 1987
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 236 (4805), 1100-1102
- https://doi.org/10.1126/science.3107130
Abstract
Linkage analysis of 15 Utah kindreds demonstrated that a gene responsible for von Recklinghausen neurofibromatosis (NF) is located near the centromere on chromosome 17. The families also gave no evidence for heterogeneity, indicating that a significant proportion of NF cases are due to mutations at a single locus. Further genetic analysis can now refine this localization and may lead to the eventual identification and cloning of the defective gene responsible for this disorder.This publication has 31 references indexed in Scilit:
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