Genetic Vulnerability and Phenotypic Expression of Depression and Risk for Ischemic Heart Disease in the Vietnam Era Twin Study of Aging
- 1 May 2010
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Psychosomatic Medicine
- Vol. 72 (4), 370-375
- https://doi.org/10.1097/psy.0b013e3181d28125
Abstract
Objective: To determine if depression contributes to incident heart disease after accounting for genetic, behavioral, and medical factors associated with both conditions. Methods: We used a prospective twin study with a 12-year follow-up. In 1992, lifetime diagnosis of depression was assessed in 1159 male-male twins and merged with longitudinal health data from the Vietnam Era Twin Registry Study of Aging. Incident heart disease was defined as having myocardial infarction, heart surgery, or angina at 12-year follow-up when twins were 55.4 years (standard deviation, 2.5 years) of age. Risks for heart disease were computed in a logistic regression model that included comparing twins at different levels of phenotypic expression of depression and varying levels of genetic vulnerability at the same time adjusting for pertinent covariates. Results: After adjusting for sociodemographics, co-occurring psychopathology, smoking, obesity, diabetes, hypertension, and social isolation, twins at high genetic risk and exposed to depression remained at greater risk of developing ischemic heart disease (IHD) (odds ratio, 2.55; 95% confidence interval, 1.44-4.49) compared with those at low genetic risk and without phenotypic expression of depression. Odds ratios suggest that twins at genetic liability but without phenotypic expression were at risk of IHD, but the effect was not statistically significant. Conclusions: A history of depression is a risk factor for incident heart disease after adjusting for numerous covariates. Twins with both high genetic vulnerability and phenotypic expression of depression were at greatest risk of IHD. Trends suggest the genetic contribution to IHD that overlaps with depression may partly explain this association, but studies in larger samples are warranted. IHD = ischemic heart disease; VET Registry = Vietnam Era Twin Registry; DSM-III-R = Diagnostic and Statistical Manual, Third Edition, Revised; VETSA = Vietnam Era Twin Study of Aging; MZ = monozygotic; DZ = dizygotic; MI = myocardial infarction.Keywords
This publication has 32 references indexed in Scilit:
- Major Depression and Coronary Artery Disease in the Swedish Twin RegistryArchives of General Psychiatry, 2009
- Common Genetic Contributions to Depressive Symptoms and Inflammatory Markers in Middle-Aged Men: The Twins Heart StudyPsychosomatic Medicine, 2009
- Association of Major Depressive Disorder with Serum Myeloperoxidase and Other Markers of Inflammation: A Twin StudyBiological Psychiatry, 2008
- Depressive Symptoms and Heart Rate Variability: Evidence for a Shared Genetic Substrate in a Study of TwinsPsychosomatic Medicine, 2008
- Association of a Serotonin Transporter Polymorphism (5-HTTLPR) With Depression, Perceived Stress, and Norepinephrine in Patients With Coronary Disease: The Heart and Soul StudyAmerican Journal of Psychiatry, 2007
- Genes, Environment, and Time: The Vietnam Era Twin Study of Aging (VETSA)Twin Research and Human Genetics, 2006
- Validity of a Self-reported History of Doctor-diagnosed AnginaJournal of Clinical Epidemiology, 1999
- Depressed Affect, Hopelessness, and the Risk of Ischemic Heart Disease in a Cohort of U.S. AdultsEpidemiology, 1993
- Familial aggregation of coronary heart disease in a high incidence area (North Karelia, Finland).Heart, 1979
- Familial Patterns in Ischaemic Heart DiseaseJournal of Epidemiology and Community Health, 1964