Dual Roles for Patched in Sequestering and Transducing Hedgehog
Open Access
- 1 November 1996
- journal article
- research article
- Published by Elsevier BV in Cell
- Vol. 87 (3), 553-563
- https://doi.org/10.1016/s0092-8674(00)81374-4
Abstract
Secreted proteins of the Hedgehog (Hh) family have diverse organizing roles in animal development. Recently, a serpentine protein Smoothened (Smo) has been proposed as a Hh receptor. Here, we present evidence that implicates another multiple-pass transmembrane protein, Patched (Ptc), in Hh reception and suggests a novel signal transduction mechanism in which Hh binds to Ptc, or a Ptc–Smo complex, and thereby induces Smo activity. Our results also show that Ptc limits the range of Hh action; we provide evidence that high levels of Ptc induced by Hh serve to sequester any free Hh and therefore create a barrier to its further movement.Keywords
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