Association of Parathyroid Hormone and 25-OH-Vitamin D Levels with Arterial Stiffness in Postmenopausal Women with Vitamin D Insufficiency
Open Access
- 1 January 2012
- journal article
- Published by Japan Atherosclerosis Society in Journal of Atherosclerosis and Thrombosis
- Vol. 19 (10), 924-931
- https://doi.org/10.5551/jat.13128
Abstract
Aim: Vitamin D insufficiency and increased parathyroid hormone (PTH) levels have been suggested as prognostic indices for cardiovascular disease. Arterial stiffness, a surrogate marker for cardiovascular disease, is often increased in patients with primary hyperparathyroidism. PTH levels increase in patients with low 25-OH-vitamin D levels, but the influence of such an increase on arterial stiffness has not been investigated in postmenopausal women with reduced 25-OH-vitamin D levels. We therefore investigated the association between PTH and aortic stiffness in postmenopausal women with reduced 25-OH-vitamin D levels. Methods: One hundred fifty postmenopausal women with 25-OH-vitamin D insufficiency (p=0.006), but the association was not significant when controlling for PTH. Significant correlates of aPWV included age, body mass index, mean arterial pressure and PTH (rho=0.39, p62 pg/mL) were associated with a 3.0-5.4-fold increased probability of having a mild-severe increase in aortic stiffness, irrespective of confounders. Conclusion: Among postmenopausal women with reduced 25-OH-vitamin D levels, elevated PTH levels were a significant predictor of aortic stiffness, irrespective of cardiovascular risk factors and of factors involved in bone formation. PTH accounted for the association between 25-OH-vitamin D levels and aortic stiffness.Keywords
This publication has 49 references indexed in Scilit:
- Markers of Mineral Metabolism Are Not Associated With Aortic Pulse Wave Velocity in Community-Living Elderly Persons: The Health Aging and Body Composition StudyAmerican Journal of Hypertension, 2011
- Impact of dialysate calcium concentration on the progression of aortic stiffness in patients on haemodialysisNephrology Dialysis Transplantation, 2011
- Cinacalcet Treatment of Primary HyperparathyroidismInternational Journal of Endocrinology, 2011
- Vitamin D InsufficiencyMayo Clinic Proceedings, 2011
- Vitamin D Insufficiency, Deficiency, and Bone HealthJournal of Clinical Endocrinology & Metabolism, 2010
- Vitamin D, Adiposity, and Calcified Atherosclerotic Plaque in African-AmericansJournal of Clinical Endocrinology & Metabolism, 2010
- Plasma Parathyroid Hormone and the Risk of Cardiovascular Mortality in the CommunityCirculation, 2009
- Vitamin D Deficiency and Risk of Cardiovascular DiseaseCirculation, 2008
- Vitamin D DeficiencyNew England Journal of Medicine, 2007
- Prevalence of Cardiovascular Risk Factors and the Serum Levels of 25-Hydroxyvitamin D in the United StatesArchives of Internal Medicine, 2007