The role of calcium in the regulation of renin secretion
- 1 January 2010
- journal article
- review article
- Published by American Physiological Society in American Journal of Physiology-Renal Physiology
- Vol. 298 (1), F1-F11
- https://doi.org/10.1152/ajprenal.00143.2009
Abstract
Renin is the enzyme which is the rate-limiting step in the formation of the hormone angiotensin II. Therefore, the regulation of renin secretion is critical in understanding the control of the renin-angiotensin-aldosterone system and its many biological and pathological actions. Renin is synthesized, stored in, and released from the juxtaglomerular (JG) cells of the kidney. While renin secretion is positively regulated by the “second messenger” cAMP, unlike most secretory cells, renin secretion from the JG cell is inversely related to the extracellular and intracellular calcium concentrations. This novel relationship is referred to as the “calcium paradox.” This review will address observations made over the past 30 years regarding calcium and the regulation of renin secretion, and focus on recent observations which address this scientific conundrum. These include 1) receptor-mediated pathways for changing intracellular calcium; 2) the discovery of a calcium-inhibitable isoform of adenylyl cyclase associated with renin in the JG cells; 3) calcium-sensing receptors in the JG cells; 4) calcium-calmodulin-mediated signals; 5) the role of phosphodiesterases; and 6) connexins, gap junctions, calcium waves, and the cortical extracellular calcium environment. While cAMP is the dominant second messenger for renin secretion, calcium appears to modulate the integrated activities of the enzymes, which balance cAMP synthesis and degradation. Thus this review concludes that calcium modifies the amplitude of cAMP-mediated renin-signaling pathways. While calcium does not directly control renin secretion, increased calcium inhibits and decreased calcium amplifies cAMP-stimulated renin secretion.Keywords
This publication has 119 references indexed in Scilit:
- Calcium-dependent phosphodiesterase 1C inhibits renin release from isolated juxtaglomerular cellsAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2009
- Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressureAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2008
- Connexin 40 and ATP-dependent intercellular calcium wave in renal glomerular endothelial cellsAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2008
- Function of connexins in the renal circulationKidney International, 2008
- Adenylyl Cyclase Isoform V Mediates Renin Release From Juxtaglomerular CellsHypertension, 2007
- Decreased Intracellular Calcium Stimulates Renin Release via Calcium-Inhibitable Adenylyl CyclaseHypertension, 2007
- Blood Pressure–Dependent Inhibition of Renin Secretion Requires A1 Adenosine ReceptorsHypertension, 2005
- Cardiovascular and Renal Phenotype in Mice With One or Two Renin GenesHypertension, 2004
- Cellular Mechanisms of Renin ReleaseClinical and Experimental Hypertension. Part A: Theory and Practice, 1983
- Isoproterenol-stimulated renin secretion in the rat: Second messenger roles of Ca and cyclic AMPLife Sciences, 1982