HIV-1 Clade B pol Evolution following Primary Infection
Open Access
- 28 June 2013
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (6), e68188
- https://doi.org/10.1371/journal.pone.0068188
Abstract
Characterize intra-individual HIV-1 subtype B pol evolution in antiretroviral naive individuals. Longitudinal cohort study of individuals enrolled during primary infection. Eligible individuals were antiretroviral naïve participants enrolled in the cohort from December 1997-December 2005 and having at least two blood samples available with the first one collected within a year of their estimated date of infection. Population-based pol sequences were generated from collected blood samples and analyzed for genetic divergence over time in respect to dual infection status, HLA, CD4 count and viral load. 93 participants were observed for a median of 1.8 years (Mean = 2.2 years, SD = 1.9 years). All participants classified as mono-infected had less than 0.7% divergence between any two of their pol sequences using the Tamura-Nei model (TN93), while individuals with dual infection had up to 7.0% divergence. The global substitution rates (substitutions/nucleotide/year) for mono and dually infected individuals were significantly different (ppol sequence data to evaluate transmission events, networks and HIV-1 dual infection.Keywords
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