Exploring the Prevalence of Ten Polyomaviruses and Two Herpes Viruses in Breast Cancer
Open Access
- 15 August 2012
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 7 (8), e39842
- https://doi.org/10.1371/journal.pone.0039842
Abstract
Several different viruses have been proposed to play a role in breast carcinogenesis. The aim of this study was to investigate the prevalence of a subset of viruses in breast cancer tissue. We investigated the prevalence of 12 DNA viruses: EBV and CMV from the Herpesviridae family and SV40, BKV, JCV, MCV, WUV, KIV, LPV, HPyV6, HPyV7, and TSV from the Polyomaviridae family in 54 fresh frozen breast tumour specimens. Relevant clinical data and basic lifestyle data were available for all patients. The tissue samples were DNA extracted and real-time PCR assays were used for viral detection. The highest prevalence, 10% (5/54), was found for EBV. MCV, HPyV6, and HPyV7 were detected in single patient samples (2% each), while WUV, KIV, JCV, BKV, LPV, SV40, TSV and CMV were not detected in the 54 breast cancer specimens analysed here. Further investigations are needed to elucidate the potential role of viruses, and particularly EBV, in breast carcinogenesis.Keywords
This publication has 31 references indexed in Scilit:
- Discovery of a New Human Polyomavirus Associated with Trichodysplasia Spinulosa in an Immunocompromized PatientPLoS Pathogens, 2010
- Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008International Journal of Cancer, 2010
- Merkel Cell Polyomavirus and Two Previously Unknown Polyomaviruses Are Chronically Shed from Human SkinCell Host & Microbe, 2010
- Breast cancer, cytomegalovirus and Epstein–Barr virus: a nested case–control studyBritish Journal of Cancer, 2010
- Lymphotropic Polyomavirus is detected in peripheral blood from immunocompromised and healthy subjectsJournal of Clinical Virology, 2010
- Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesisThe Journal of Pathology, 2009
- Clonal Integration of a Polyomavirus in Human Merkel Cell CarcinomaScience, 2008
- Identification of a Novel Polyomavirus from Patients with Acute Respiratory Tract InfectionsPLoS Pathogens, 2007
- Identification of a Third Human PolyomavirusJournal of Virology, 2007
- The global health burden of infection‐associated cancers in the year 2002International Journal of Cancer, 2006