Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat
- 23 November 1984
- journal article
- Published by Elsevier BV in Neuroscience Letters
- Vol. 52 (1-2), 199-204
- https://doi.org/10.1016/0304-3940(84)90374-4
Abstract
Using immunohistochemistry evidence was obtained for the coexistence of calcitonin gene-related peptide (CGRP)- and substance P (SP)-like immunoreactivity in spinal sensory neurons. Analysis of caudally directed biting and scratching (CBS) behavior was carried out after intrathecal administration of CGRP and SP alone or in combination. Thus, SP (up to 20 μg) alone caused CBS only for a few minutes after injection, whereas SP (10 μg) plus CGRP (20 μg) caused a response with a duration up to 40 min. CGRP (20 μg) alone had no effects in this model. These findings provide support for a possible interaction of the two peptides at synapses in the dorsal horn of the spinal cord.Keywords
This publication has 14 references indexed in Scilit:
- Calcitonin gene-related peptide in the human thyroid, pituitary and brainMolecular and Cellular Endocrinology, 1984
- Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptideNature, 1983
- Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processingNature, 1983
- Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide productsNature, 1982
- Intrathecal substance P and somatostatin in rats: Behaviors indicative of sensationPeptides, 1982
- Immunohistochemical studies on the effect of capsaicin on spinal and medullary peptide and monoamine neurons using antisera to substance P, gastrin/CCK, somatostatin, VIP, enkephalin, neurotensin and 5-hydroxytryptamineJournal of Neurocytology, 1981
- Intrathecal substance P elicits a caudally-directed biting and scratching behavior in miceBrain Research, 1981
- Behavioral evidence that substance P may be a spinal cord sensory neurotransmitterBrain Research, 1981
- Substance P-immunoreactive nerve fibers in the heartNeuroscience Letters, 1980
- Peptidergic neuronesNature, 1980