White Blood Cell Count and Risk for All-Cause, Cardiovascular, and Cancer Mortality in a Cohort of Koreans
Open Access
- 12 October 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Epidemiology
- Vol. 162 (11), 1062-1069
- https://doi.org/10.1093/aje/kwi326
Abstract
The authors conducted a 10-year prospective cohort study of mortality in relation to white blood cell counts of 437,454 Koreans, aged 40–95 years, who received health insurance from the National Health Insurance Corporation and were medically evaluated in 1993 or 1995, with white blood cell measurement. The main outcome measures were mortality from all causes, all cancers, and all atherosclerotic cardiovascular diseases (ASCVD). Hazard ratios and 95% confidence intervals were calculated using Cox proportional hazards models with adjustment for age and potential confounders. During follow-up, 48,757 deaths occurred, with 15,507 deaths from cancer and 11,676 from ASCVD. For men and women, white blood cell count was associated with all-cause mortality and ASCVD mortality but not with cancer mortality. In healthy nonsmokers, a graded association between a higher white blood cell count and a higher risk of ASCVD was observed in men (highest vs. lowest quintile: hazard ratio = 2.10, 95% confidence interval: 1.50, 2.94) and in women (hazard ratio = 1.35, 95% confidence interval: 1.17, 1.56). In healthy smokers, a graded association between a higher white blood cell count and a higher risk of ASCVD was also observed in men (highest vs. lowest quintile: hazard ratio = 1.46, 95% confidence interval: 1.25, 1.72). These findings indicate that the white blood cell count is an independent risk factor for all-cause mortality and for ASCVD mortality.Keywords
This publication has 27 references indexed in Scilit:
- Leukocyte count and coronary heart disease: Implications for risk assessmentJournal of the American College of Cardiology, 2004
- Leukocyte count, diabetes mellitus and age are strong predictors of stroke in a rural population in southern Italy: an 8-year follow-upAtherosclerosis, 2001
- White blood cell count: An independent predictor of coronary heart disease mortality among a national cohortJournal of Clinical Epidemiology, 2001
- Association of white blood cell count with increased mortality in acute myocardial infarction and unstable angina pectorisThe American Journal of Cardiology, 2001
- White Blood Cell Count and the Risk of Coronary Heart Disease and All-Cause Mortality in Elderly MenArteriosclerosis, Thrombosis, and Vascular Biology, 1996
- White blood cell count and cardiovascular disease. Insights from the Framingham StudyJAMA, 1992
- White blood cell count as a predictor of mortality: Results over 18 years from the normative aging studyJournal of Clinical Epidemiology, 1990
- Leukocytes and the risk of ischemic diseasesJAMA, 1987
- Prognostic importance of the white blood cell count for coronary, cancer, and all-cause mortalityJAMA, 1985
- Leukocyte counts and cerebrovascular diseaseJournal of Chronic Diseases, 1982