Study of Feasibility and Safety of Higher-Dose Dexmedetomidine in Special Outpatient Examination of Pediatric Ophthalmology
Open Access
- 8 April 2019
- journal article
- research article
- Published by Hindawi Limited in Journal of Ophthalmology
- Vol. 2019, 1-6
- https://doi.org/10.1155/2019/2560453
Abstract
Objective. To investigate the feasibility and safety of higher-dose dexmedetomidine in ophthalmological outpatient examination of children with cataract. Methods. 100 cases of children were recruited in the study and randomly equally divided into two groups. One group was given 2 μg/kg intranasal dexmedetomidine anesthesia, while the other group was under 3 μg/kg. The dosage of dexmedetomidine was calculated by the same anesthesiologist according to the weight of patient. After sufficient sedation, the same ophthalmologist performed ocular examinations manually, including intraocular pressure, keratometry, axial length, and corneal thickness and recorded the ocular position score during intraocular pressure measurement and corneal thickness measurement. Other variables were sedation onset time, recovery time, vital signs, and side effects. Results. In intraocular pressure measurement, only one case in the 2 μg/kg group did not complete the examination, while all cases in the 3 μg/kg group completed the examination and the difference of the success rate between the two groups was nonsignificant (). The success rates of the 3 μg/kg group in corneal curvature, axial length, and corneal thickness examination were 96%, 92%, and 86%, respectively, which were significantly higher than those of the 2 μg/kg group (22%, 18%, and 4%). The average onset time of sedation in the 3 μg/kg group was 15.42 ± 2.09 minutes, which was significantly shorter than that in the 2 μg/kg group (19.52 ± 2.43 minutes, ). The average time of completing all examinations in the 3 μg/kg group was 18.36 ± 4.01 minutes, which was significantly shorter than that in the 2 μg/kg group (22.62 ± 4.13 min, ). The recovery time of group 3 μg/kg was 90.62 ± 27.80 min, which was significantly longer than that of group 2 μg/kg (49.20 ± 15.50 min). Vital signs such as pulse, blood pressure, oxygen saturation, and heart rate kept in normal range throughout the tests, and no obvious side effects were observed. Conclusion. 3 μg/kg intranasal dexmedetomidine had a higher sedation success rate and quality than 2 μg/kg did in pediatric ocular examinations, without any obvious side effects.Keywords
This publication has 18 references indexed in Scilit:
- Chloral hydrate enteral infusion for sedation in ventilated children: the CHOSEN pilot studyCritical Care, 2017
- Safety and efficacy of chloral hydrate for procedural sedation in paediatric ophthalmology: a systematic review and meta-analysisBritish Journal of Ophthalmology, 2017
- Clinical Pharmacokinetics and Pharmacodynamics of DexmedetomidineClinical Pharmacokinetics, 2017
- Rescue Sedation With Intranasal Dexmedetomidine for Pediatric Ophthalmic Examination After Chloral Hydrate Failure: A Randomized, Controlled TrialClinical Therapeutics, 2016
- Long-term Results of Pediatric Cataract Surgery and Primary Intraocular Lens Implantation From 7 to 22 Months of LifeJAMA Ophthalmology, 2015
- Intranasal dexmedetomidine for sedation in children undergoing transthoracic echocardiography study—a prospective observational studyPediatric Anesthesia, 2015
- Complications in the First 5 Years Following Cataract Surgery in Infants With and Without Intraocular Lens Implantation in the Infant Aphakia Treatment StudyAmerican Journal of Ophthalmology, 2014
- Dexmedetomidine SedationPediatric Emergency Care, 2012
- Intranasal dexmedetomidine for paediatric sedation for diagnostic magnetic resonance imaging studiesIndian Journal of Anaesthesia, 2012
- A comparison of the rate of refractive growth in pediatric aphakic and pseudophakic eyesOphthalmology, 2000