Post-amphetamine depression of self-stimulation responding from the substantia nigra: Reversal by tricyclic antidepressants
- 1 September 1980
- journal article
- research article
- Published by Elsevier BV in Pharmacology Biochemistry and Behavior
- Vol. 13 (3), 379-383
- https://doi.org/10.1016/0091-3057(80)90242-7
Abstract
The effects of long-term amphetamine treatment were examined on self-stimulation responding from the substantia nigra. Rates of self-stimulation responding were substantially depressed among rats chronically treated with amphetamine and tested in the absence of the drug. When rats were subsequently retested after a two day hiatus in which they received imipramine or amitriptyline, the post-amphetamine depression of rates of self-stimulation responding was mitigated. The efficacy of imipramine and amitriptyline in reversing the post-amphetamine depression of self-stimulation responding was also evident during a continuation of the drug (imipramine or amitriptyline)/test sequence, for seven test sessions. The results of the present investigation were related to changes in dopamine and acetycholine neurotransmission following long-term amphetamine treatment.Keywords
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