Prognostic Significance of CD24 Expression in Gastric Carcinoma
Open Access
- 1 January 2004
- journal article
- Published by Korean Cancer Association in Cancer Research and Treatment
- Vol. 36 (5), 298-302
- https://doi.org/10.4143/crt.2004.36.5.298
Abstract
The human CD24 antigen is a small heavily glycosylated cell surface protein, which is expressed in hematological malignancies, as well as in a large variety of solid tumors. Its expression is now known to be related to the prognosis of several kinds of tumors. This study is designed to examine the prognostic significance of CD24 in Korean gastric cancer patients. In the present study, we examined CD24 expression in 300 consecutive cases of gastric carcinoma by immunohistochemical staining using the tissue-array method. We also investigated the clinicopathological profiles related to CD24 expression. One hundred and three cases out of 300 (34.3%) showed the positive expression of CD24. The altered expression of CD24 was significantly associated with differentiated cancer (p=0.003), the intestinal subtype according to the Lauren classification (p<0.001), the advanced stage cancer (p=0.027), with lymphatic invasion (p=0.038) and with vascular invasion (p=0.006). The survival analysis revealed that the patients with CD24 positive expression showed significantly poorer survival than those without CD24 expression. Moreover, a combined evaluation revealed that PTEN+/CD24- cases showed the best survival compared to other groups (p=0.01). Positive CD24 expression occurs in a subset of gastric carcinomas and it correlates significantly with lymphatic invasion, blood vessel invasion and poor survival.Keywords
This publication has 16 references indexed in Scilit:
- CD24 expression is a significant predictor of PSA relapse and poor prognosis in low grade or organ confined prostate cancerThe Prostate, 2003
- Tumour suppressor gene expression correlates with gastric cancer prognosisThe Journal of Pathology, 2003
- CD24 Is Expressed in Ovarian Cancer and Is a New Independent Prognostic Marker of Patient SurvivalThe American Journal of Pathology, 2002
- Promoter Methylation and Silencing of PTEN in Gastric CarcinomaLaboratory Investigation, 2002
- CD24 Induces Apoptosis in Human B Cells Via the Glycolipid-Enriched Membrane Domains/Rafts-Mediated Signaling SystemThe Journal of Immunology, 2001
- Gene expression patterns associated with the metastatic phenotype in rodent and human tumors.2001
- The CD24/P-selectin binding pathway initiates lung arrest of human A125 adenocarcinoma cells.2000
- Microdomains in lymphocyte signalling: beyond GPI-anchored proteinsImmunology Today, 2000
- CD24 is a marker for human breast carcinomaCancer Letters, 1999
- [PTEN: a tumor suppressor with original properties].1999