Alternative Promoters Influence Alternative Splicing at the Genomic Level
Open Access
- 18 June 2008
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 3 (6), e2377
- https://doi.org/10.1371/journal.pone.0002377
Abstract
More and more experiments have shown that transcription and mRNA processing are not two independent events but are tightly coupled to each other. Both promoter and transcription rate were found to influence alternative splicing. More than half of human genes have alternative promoters, but it is still not clear why there are so many alternative promoters and what their biological roles are. In this study, we explored whether there is a functional correlation between alternative promoters and alternative splicing by a genome-wide analysis of human and mouse genes. We constructed a large data set of genes with alternative promoter and alternative splicing annotations. By analyzing these genes, we showed that genes with alternative promoters tended to demonstrate alternative splicing compare to genes with single promoter, and, genes with more alternative promoters tend to have more alternative splicing variants. Furthermore, transcripts from different alternative promoters tended to splice differently. Thus at the genomic level, alternative promoters are positively correlated with alternative splicing.This publication has 36 references indexed in Scilit:
- Alternative Splicing: New Insights from Global AnalysesCell, 2006
- Genome-Wide Survey of Human Alternative Pre-mRNA Splicing with Exon Junction MicroarraysScience, 2003
- Mechanisms of Alternative Pre-Messenger RNA SplicingAnnual Review of Biochemistry, 2003
- Pre-mRNA splicing and human diseaseGenes & Development, 2003
- Alternative splicing in the testesCurrent Opinion in Genetics & Development, 2002
- A genomic view of alternative splicingNature Genetics, 2002
- Aberrant Splicing of tau Pre-mRNA Caused by Intronic Mutations Associated with the Inherited Dementia Frontotemporal Dementia with Parkinsonism Linked to Chromosome 17Molecular and Cellular Biology, 2000
- ALTERNATIVE SPLICING OF PRE-mRNA: Developmental Consequences and Mechanisms of RegulationAnnual Review of Genetics, 1998
- Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicingNature, 1993
- SR proteins: a conserved family of pre-mRNA splicing factors.Journal of Bone and Joint Surgery, 1992