Lysyl Oxidase Mediates Hypoxic Control of Metastasis
Open Access
- 1 November 2006
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 66 (21), 10238-10241
- https://doi.org/10.1158/0008-5472.can-06-3197
Abstract
Hypoxic cancer cells pose a great challenge to the oncologist because they are especially aggressive, metastatic, and resistant to therapy. Recently, we showed that elevation of the extracellular matrix protein lysyl oxidase (LOX) correlates with metastatic disease and is essential for hypoxia-induced metastasis. In an orthotopic rodent model of breast cancer, a small-molecule or antibody inhibitor of LOX abolished metastasis, offering preclinical validation of this enzyme as a therapeutic target. (Cancer Res 2006; 66(21): 10238-41)This publication has 17 references indexed in Scilit:
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