Control of Neutrophil Inflammation at Mucosal Surfaces by Secreted Epithelial Products
Open Access
- 1 January 2013
- journal article
- Published by Frontiers Media SA in Frontiers in Immunology
- Vol. 4, 220
- https://doi.org/10.3389/fimmu.2013.00220
Abstract
The human intestine is a large and delicately balanced organ, responsible for efficiently absorbing nutrients and selectively eliminating disease-causing pathogens. The gut architecture consists of a single layer of epithelial cells that forms a barrier against the food antigens and resident microbiota within the lumen. This barrier is augmented by a thick layer of mucus on the luminal side and an underlying lamina propria containing a resident population of immune cells. Attempted breaches of the intestinal barrier by pathogenic bacteria result in the rapid induction of a coordinated innate immune response that includes release of antimicrobial peptides, activation of pattern recognition receptors, and recruitment of various immune cells. In recent years, the role of epithelial cells in initiating this immune response has been increasingly appreciated. In particular, epithelial cells are responsible for the release of a variety of factors that attract neutrophils, the body’s trained bacterial killers. In this review we will highlight recent research that details a new understanding of how epithelial cells directionally secrete specific compounds at distinct stages of the inflammatory response in order to coordinate the immune response to intestinal microbes. In addition to their importance during the response to infection, evidence suggests that dysregulation of these pathways may contribute to pathologic inflammation during inflammatory bowel disease. Therefore, a continued understanding of the mechanisms by which epithelial cells control neutrophil migration into the intestine will have tremendous benefits in both the understanding of biological processes and the identification of potential therapeutic targets.This publication has 63 references indexed in Scilit:
- Enteroaggregative Escherichia coli promotes transepithelial migration of neutrophils through a conserved 12-lipoxygenase pathwayCellular Microbiology, 2011
- Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxificationProceedings of the National Academy of Sciences of the United States of America, 2010
- Distinct Isoforms of Phospholipase A 2 Mediate the Ability of Salmonella enterica Serotype Typhimurium and Shigella flexneri To Induce the Transepithelial Migration of NeutrophilsInfection and Immunity, 2008
- The Physiology of Leukocyte Recruitment: An In Vivo PerspectiveThe Journal of Immunology, 2008
- Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolutionThe FASEB Journal, 2007
- Neutrophils and immunity: challenges and opportunitiesNature Reviews Immunology, 2006
- Neutrophil-mediated epithelial injury during transmigration: role of elastaseAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2001
- Apical Secretion of a Pathogen-Elicited Epithelial Chemoattractant Activity in Response to Surface Colonization of Intestinal Epithelia by Salmonella typhimuriumThe Journal of Immunology, 1998
- Characterization of a specific ligand for P-selectin on myeloid cells. A minor glycoprotein with sialylated O-linked oligosaccharidesOnline Journal of Public Health Informatics, 1993
- Degree of Neutrophil Chemotaxis Is Dependent upon the Chemoattractant and BarrierAmerican Journal of Respiratory Cell and Molecular Biology, 1992