The spectrum of malignancies in HIV‐infected patients in 2006 in France: The ONCOVIH study
Open Access
- 4 January 2011
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 129 (2), 467-475
- https://doi.org/10.1002/ijc.25903
Abstract
Since no large descriptive studies of incident cancers in HIV‐infected patients are available in France, the nationwide cross‐sectional ONCOVIH study aimed to prospectively report new malignancies diagnosed in HIV‐infected patients in cancer centers and HIV/AIDS centers. We estimated the number of cancers in France for the year 2006 using the capture–recapture methods with two sources: ONCOVIH and the FHDH ANRS‐CO4 cohort, as well as the completeness of the sources. Incidence and relative risks (RR) to the general population were estimated. In 2006, 672 new malignancies in 668 patients were reported in ONCOVIH; the most common were non Hodgkin's lymphoma (NHL, 21.5%), Kaposi's sarcoma (KS, 16.0%), lung cancer (9.4%), anal cancer (8.2%), Hodgkin's lymphoma (7.6%), skin cancers excluding melanoma (6.8%), and liver cancer (5.6%). Based on the capture‐recapture approach, the estimated number of malignancies was 1320 and non‐AIDS‐defining malignancies (NADM) represented 68% of cases. The overall ascertainment of malignancies were 53%, and 59%, in the ONCOVIH study, and the FHDH ANRS‐CO4 cohort, respectively. The estimated incidence of cancer among HIV‐infected patients was 14 per 1000 person‐years. Compared with the general population, the estimated RR in HIV–infected patients was 3.5 (95%CI 3.3–3.8) in men and 3.6 (95%CI 3.2–4.0) in women, and was particularly elevated in younger patients. Even in the era of combined antiretroviral therapy, the incidence of cancer is higher in HIV‐infected persons than in the general population. A large variety of malignancies were diagnosed, and the majority were NADM.This publication has 22 references indexed in Scilit:
- Ethics and observational studies in medical research: various rules in a common frameworkInternational Journal of Epidemiology, 2009
- Changes in Cancer Mortality among HIV‐Infected Patients: The Mortalité 2005 SurveyClinical Infectious Diseases, 2009
- AIDS-Related Malignancies: State of the Art and Therapeutic ChallengesJournal of Clinical Oncology, 2008
- Changes in Causes of Death Among Adults Infected by HIV Between 2000 and 2005: The “Mortalité 2000 and 2005” Surveys (ANRS EN19 and Mortavic)JAIDS Journal of Acquired Immune Deficiency Syndromes, 2008
- Marked increase in the incidence of invasive anal cancer among HIV-infected patients despite treatment with combination antiretroviral therapyAIDS, 2008
- Cancer incidence and mortality in France over the period 1980–2005Revue D'epidemiologie Et de Sante Publique, 2008
- Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDSBlood, 2006
- Trends in cancer risk among people with AIDS in the United States 1980–2002AIDS, 2006
- Cancer Risk in the Swiss HIV Cohort Study: Associations With Immunodeficiency, Smoking, and Highly Active Antiretroviral TherapyJNCI Journal of the National Cancer Institute, 2005
- Incidence of Non–AIDS-Defining Cancers Before and During the Highly Active Antiretroviral Therapy Era in a Cohort of Human Immunodeficiency Virus–Infected PatientsJournal of Clinical Oncology, 2003