Oral glycopyrrolate for the treatment of chronic severe drooling caused by neurological disorders in children
Open Access
- 1 September 2011
- journal article
- review article
- Published by Taylor & Francis Ltd in Neuropsychiatric Disease and Treatment
- Vol. 7 (1), 543-547
- https://doi.org/10.2147/ndt.s14028
Abstract
Excessive drooling may complicate the care of children with chronic neurological conditions by socially isolating both patients and families and by causing secondary dermatitis and infection. Normal control of saliva requires normal integrity of oral structures, normal oropharyngeal sensation, and motor functioning, as well as normal cognitive awareness and rate of salivary production. Glycopyrrolate is an anticholinergic medication with a quaternary structure that recently received Food and Drug Administration approval to treat sialorrhea due to neurological problems in children ages 3–16 years. This review summarizes the few published studies of safety and efficacy of glycopyrrolate for drooling in children with chronic neurological conditions.Keywords
This publication has 19 references indexed in Scilit:
- Stability of extemporaneously prepared glycopyrrolate oral suspensionsAmerican Journal of Health-System Pharmacy, 2011
- Management of drooling in childrenArchives of Disease in Childhood: Education & Practice, 2010
- Drooling, saliva production, and swallowing in cerebral palsyDevelopmental Medicine and Child Neurology, 2004
- The Treatment of Drooling by Ultrasound‐Guided Intraglandular Injections of Botulinum Toxin Type A Into the Salivary GlandsThe Laryngoscope, 2003
- Sialorrhea — Therapeutic Drug OptionsAnnals of Pharmacotherapy, 2002
- Postparotidectomy fistula: a different treatment for an old problemInternational Journal of Pediatric Otorhinolaryngology, 1999
- Glycopyrrolate Treatment of Chronic DroolingArchives of Pediatrics & Adolescent Medicine, 1996
- EFFICACY OF BENZTROPINE THERAPY FOR DROOLINGDevelopmental Medicine and Child Neurology, 1989
- Three treatment approaches and clinical factors in the reduction of droolingDysphagia, 1988
- Drooling in children with cerebral palsy.1980