Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging
Open Access
- 21 February 2020
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Cell and Developmental Biology
- Vol. 8, 107
- https://doi.org/10.3389/fcell.2020.00107
Abstract
Aging is associated with high prevalence of chronic degenerative diseases that take a large part of the increasing burden of morbidities in a growing demographic of elderly people. Aging is a complex process that involves cell autonomous and cell non-autonomous mechanisms where senescence plays an important role. Senescence is characterized by the loss of proliferative potential, resistance to cell death by apoptosis and expression of a senescence-associated secretory phenotype (SASP). SASP includes pro-inflammatory cytokines and chemokines, tissue-damaging proteases, growth factors; all contributing to tissue microenvironment alteration and loss of tissue homeostasis. Emerging evidence suggests that the changes in the number and composition of extracellular vesicles (EVs) released by senescent cells contribute to the adverse effects of senescence in aging. In addition, age-related alterations in mesenchymal stem/stromal cells (MSCs) have been associated to dysregulated functions. The loss of functional stem cells necessary to maintain tissue homeostasis likely directly contributes to aging. In this review, we will focus on the characteristics and role of EVs isolated from senescent MSCs, the potential effect of MSC-derived EVs in aging and discuss their therapeutic potential to improve age-related diseases.Funding Information
- Agence Nationale de la Recherche
This publication has 67 references indexed in Scilit:
- Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction modelJournal of Molecular Medicine, 2013
- Programmed Cell Senescence during Mammalian Embryonic DevelopmentCell, 2013
- The Hallmarks of AgingCell, 2013
- Oncogene- and tumor suppressor gene-mediated suppression of cellular senescenceSeminars in Cancer Biology, 2011
- The ageing systemic milieu negatively regulates neurogenesis and cognitive functionNature, 2011
- Senescent mesenchymal cells accumulate in human fibrosis by a telomere‐independent mechanism and ameliorate fibrosis through matrix metalloproteinasesThe Journal of Pathology, 2010
- Senescence-Associated Exosome Release from Human Prostate Cancer CellsCancer Research, 2008
- Expression of RAB27B is up-regulated in senescent human cellsMechanisms of Ageing and Development, 2006
- Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statementCytotherapy, 2006
- Oncogene-induced senescence as an initial barrier in lymphoma developmentNature, 2005