Kaposi's sarcoma in AIDS: basement membrane and endothelial cell markers in late‐stage lesions
- 1 July 1988
- journal article
- research article
- Published by Wiley in Journal of Oral Pathology & Medicine
- Vol. 17 (6), 266-272
- https://doi.org/10.1111/j.1600-0714.1988.tb01535.x
Abstract
Early-stage lesions of Kaposi''s sarcoma (KS) are composed of single-layered, highly flattened cells lining collagen bundles, whereas late-stage lesions contain densely packed, spindle-shaped cells. We examined the progression of KS lesions in oral mucosa and lymph nodes from patients with AIDS, using antibodies specific for blood vascular endothelial cells (Factor VIII-related antigen) and their basement membrane (Type IV collagen and laminin). In addition, the plant lectin Ulex europaeus, which selectively stains blodd vessels, was also used. In early-stage KS lesion, fibronectin, laminin and Type IV collagen were co-distributed at the interface between KS cells and collagen bundles; Factor VIII-related antigen and Ulex europaeus lectin staining was present in vascular channels and in the KS cells. However, in late-stage lesions, few if any KS cells stained with antibody to Factor VIII-associated antigen, although endothelial cells lining blood vessels were positive. Strong staining for laminin and Type IV collagen was present in a pericellular pattern throughout the nodular late-stage lesions. Since lymphatic capillary endothelium does not produce basement-membrane-specific macromolecules, these results support the conclusion that KS cells are related to blood vascular endothelium but eventually lose certain endothelium-specific markers as the cells are transformed into the spindle-shaped cell type.This publication has 35 references indexed in Scilit:
- Type IV collagen synthesis by cultured human microvascular endothelial cells and its deposition into the subendothelial basement membraneBiochemistry, 1985
- Basement Membrane and Connective Tissue Proteins in Early Lesions of Kaposi's Sarcoma Associated with AIDSJournal of Investigative Dermatology, 1985
- Distribution of fibronectin and laminin in oral leukoplakia and carcinomaJournal of Oral Pathology & Medicine, 1985
- Immunological studies of homosexual men with immunodeficiency and Kaposi's sarcomaClinical Immunology and Immunopathology, 1983
- Kaposi's sarcoma in homosexual men: An immunohistochemical studyJournal of the American Academy of Dermatology, 1983
- Blood Vessel Fibronectin Increases in Conjunction with Endothelial Cell Proliferation and Capillary Ingrowth During Wound HealingJournal of Investigative Dermatology, 1982
- Distribution of a major connective tissue protein, fibronectin, in normal human tissues.The Journal of Experimental Medicine, 1978
- Tissue culture of Kaposi's sarcomaArchives of Dermatology, 1972
- Origin of Kaposi's Sarcoma from the Reticulo-endothelial SystemNature, 1967
- The origin of Kaposi's hæmangiosarcoma: A histochemical studyThe Journal of Pathology and Bacteriology, 1959