Synthesis of pyrazolines by a site isolated resin-bound reagents methodology
- 26 May 2010
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 8 (14), 3287-3293
- https://doi.org/10.1039/c004704j
Abstract
The elaboration of biologically important 3,4-substituted pyrazolines was achieved by an organocatalysed aza-Michael/transimination domino sequence between hydrazones and enones making use of a mixture of heterogeneous resin-bound acid/base reagents. This methodology nicely illustrates the site isolation concept of supported reagents allowing the simultaneous use of otherwise destructive reactive functionalities.Keywords
This publication has 44 references indexed in Scilit:
- TBD-organocatalysed synthesis of pyrazolinesOrganic & Biomolecular Chemistry, 2009
- Sequential One‐Pot Reactions Using the Concept of “Site Isolation”Angewandte Chemie-International Edition, 2006
- Discovery of non-steroidal mifepristone mimetics: Pyrazoline-based PR antagonistsBioorganic & Medicinal Chemistry Letters, 2005
- Polymer-Supported Organic CatalystsChemical Reviews, 2003
- Process Optimization and Synthesis of 3-(4-Fluorophenyl)-4,5-dihydro-N-[4-(tri- fluoromethyl)phenyl]-4-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazole-1-carboxamideOrganic Process Research & Development, 2003
- Synthesis of 2‐pyrazolines by the reactions of α,β‐unsaturated aldehydes, ketones, and esters with diazoalkanes, nitrile imines, and hydrazinesJournal of Heterocyclic Chemistry, 2002
- Clean three-step synthesis of 4,5-dihydro-1H-pyrazoles starting from alcohols using polymer supported reagentsJournal of the Chemical Society, Perkin Transactions 1, 1998
- Reinvestigation of the Reaction of 3-Hydroxy-2-methyl-1-aryl-1-propanones and Related Compounds with Hydrazine and Carboxylic AcidsSynthesis, 1989
- Concurrent strong acid and base catalysis. Synthesis of cyclopentenonesThe Journal of Organic Chemistry, 1981
- Sequential multistep reactions catalyzed by polymer-anchored homogeneous catalystsJournal of the American Chemical Society, 1975