Nuclear factor I/B is an oncogene in small cell lung cancer
Open Access
- 15 July 2011
- journal article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 25 (14), 1470-1475
- https://doi.org/10.1101/gad.2046711
Abstract
Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. Using a genetically engineered mouse model of SCLC driven by conditional deletion of Trp53 and Rb1 in the lung, we identified several frequent, high-magnitude focal DNA copy number alterations in SCLC. We uncovered amplification of a novel, oncogenic transcription factor, Nuclear factor I/B (Nfib), in the mouse SCLC model and in human SCLC. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation.Keywords
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