Diterpenes from the Roots of Euphorbia kansui and Their in Vitro Effects on the Cell Division of Xenopus (2)
- 1 January 2003
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 51 (8), 935-941
- https://doi.org/10.1248/cpb.51.935
Abstract
Four new ingenane-type diterpenes, 3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoyl-20-O-acetylingenol (1), 3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoyl-20-deoxyingenol (2), 3-O-(2E,4Z-decadienoyl)-20-deoxyingenol (3), and 3-O-(2E,4E-decadienoyl)-20-deoxyingenol (4), two new jatrophane-type diterpenes, kansuinins D (9) and E (10), and four known ingenane-type diterpenes were isolated from the root of Euphorbia kansui. Their structures were elucidated by spectroscopic and chemical analysis, and individual Xenopus cells at the blastular stage were cultured with the diterpenes to test for biological activity. 20-Deoxyingenol diterpenes 3 and 4 induced the greatest cell cleavage arrest (0.5 micro g/ml of each compound resulted in >75% cleavage arrest), but cell cleavage inhibitory activity became weak when C-16 had an acyl residue. In contrast, the jatrophane diterpene kansuinin D (9) showed no activity.Keywords
This publication has 11 references indexed in Scilit:
- Euphane and Tirucallane Triterpenes from the Roots of Euphorbia kansui and Their in Vitro Effects on the Cell Division of XenopusJournal of Natural Products, 2003
- Diterpenes from the Roots of Euphorbia kansui and Their in Vitro Effects on the Cell Division of XenopusJournal of Natural Products, 2002
- Diterpenes from Euphorbia paraliasPhytochemistry, 1998
- Macrocyclic Diterpene Polyesters of the Jatrophane Type from Euphorbia esulaJournal of Natural Products, 1997
- Novel Saponins Hainaneosides A and B Isolated from Marsdenia hainanensisJournal of Natural Products, 1997
- Stimulatory Effects of Ingenols fromEuphorbia kansuion the Expression of Macrophage Fc ReceptorPlanta Medica, 1992
- Antitumor Agents, 119. Kansuiphorins A and B, Two Novel Antileukemic Diterpene Esters from Euphorbia kansuiJournal of Natural Products, 1991
- A major developmental transition in early xenopus embryos: II. control of the onset of transcriptionCell, 1982
- A major developmental transition in early xenopus embryos: I. characterization and timing of cellular changes at the midblastula stageCell, 1982
- Highly irritant ingenane type diterpene esters fromEuphorbia cyparissias L.Cellular and Molecular Life Sciences, 1981