In vivo imaging and tumor therapy with the sodium iodide symporter
- 27 October 2003
- journal article
- review article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 90 (6), 1079-1086
- https://doi.org/10.1002/jcb.10714
Abstract
There has been great progress in the design of vectors for cancer gene therapy. However, it has been difficult to translate success in the laboratory into clinical practice. A major hurdle in understanding these failures has been the relative difficulty in monitoring repeatedly and non‐invasively the biodistribution, gene expression and replication of these viral vector systems. With the advent of molecular imaging technology, this deficiency is being rapidly rectified. A number of reporter genes have been used to monitor gene expression. In this review, we discuss the role of the sodium iodide symporter (NIS) as a reporter and therapeutic gene for cancer gene therapy when combined with various radioactive isotopes.Keywords
This publication has 30 references indexed in Scilit:
- Genetically targeted radiotherapy for multiple myelomaBlood, 2003
- In vivo imaging and radioiodine therapy following sodium iodide symporter gene transfer in animal model of intracerebral gliomasGene Therapy, 2002
- In vivo sodium iodide symporter gene therapy of prostate cancerGene Therapy, 2001
- Noninvasive, quantitative imaging in living animals of a mutant dopamine D2 receptor reporter gene in which ligand binding is uncoupled from signal transductionGene Therapy, 2001
- Cloning of the Mouse Sodium Iodide SymporterThyroid®, 2001
- Experimental targeted radioiodide therapy following transfection of the sodium iodide symporter gene: Effect on clonogenicity in both two-and three-dimensional modelsCancer Gene Therapy, 2000
- Analysis of Human Sodium Iodide Symporter Immunoreactivity in Human Exocrine GlandsJournal of Clinical Endocrinology & Metabolism, 1999
- N-linked Glycosylation of the Thyroid Na+/I− Symporter (NIS)Journal of Biological Chemistry, 1998
- Binding of Immunoglobulin G from Patients with Autoimmune Thyroid Disease to Rat Sodium-Iodide Symporter Peptides: Evidence for the Iodide Transporter as an Autoantigen*Thyroid®, 1997
- Cloning of the Human Sodium Iodide SymporterBiochemical and Biophysical Research Communications, 1996