Mucins and inflammatory bowel disease
Open Access
- 1 August 2000
- journal article
- review article
- Published by Oxford University Press (OUP)
- Vol. 76 (898), 473-478
- https://doi.org/10.1136/pmj.76.898.473
Abstract
There is a layer of mucus lining the gastrointestinal tract, which acts as both a lubricant and as a physical barrier between luminal contents and the mucosal surface. The mucins that make up this layer consist of a protein backbone with oligosaccharides attached to specific areas of the protein core. These areas are called the variable number tandem repeat regions. The degree of glycosylation of the mucins is central to their role in the mucus barrier. The oligosaccharides are variable and complex. It has been demonstrated that the degree of sulphation and sialylation and the length of the oligosaccharide chains all vary in inflammatory bowel disease. These changes can alter the function of the mucins. Mucins are broadly divided into two groups, those that are secreted and those that are membrane bound. The major mucins present in the colorectum are MUC1, MUC2, MUC3, and MUC4. Trefoils are a group of small peptides that have an important role in the mucus layer. Three trefoils have been demonstrated so far. They seem to play a part in mucosal protection and in mucosal repair. They may help to stabilise the mucus layer by cross linking with mucins to aid formation of stable gels. Trefoils can be expressed in the ulcer associated cell lineage, a glandular structure that can occur in the inflamed mucosa. There seem to be differences in the expression of trefoils in the colon and the small bowel, which may imply different method of mucosal repair.Keywords
This publication has 47 references indexed in Scilit:
- Mucins and inflammatory bowel diseaseQJM: An International Journal of Medicine, 1997
- Healing the epithelium: Solving the problem from two sidesThe Esophagus, 1997
- Human Mucin Genes Assigned to 11p15.5: Identification and Organization of a Cluster of GenesGenomics, 1996
- The Trefoil Peptide FamilyAnnual Review of Physiology, 1996
- The epithelial mucin, MUC1, of milk, mammary gland and other tissuesBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1995
- South Asian and European colitics show characteristic differences in colonic mucus glycoprotein type and turnover.Gut, 1995
- Increased Rate of Sialylation of Colonic Mucin by Cultured Ulcerative Colitis Mucosal ExplantsDigestion, 1995
- Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis.Gut, 1994
- Mortality in patients with ulcerative colitis in Leicestershire, 1972?1989Digestive Diseases and Sciences, 1993
- Incidence of cancer in Bradford Asians.Journal of Epidemiology and Community Health, 1990