Erythroid and megakaryocytic transformation
Open Access
- 15 October 2007
- journal article
- review article
- Published by Springer Science and Business Media LLC in Oncogene
- Vol. 26 (47), 6803-6815
- https://doi.org/10.1038/sj.onc.1210763
Abstract
Red blood cells and megakaryocytes arise from a common precursor, the megakaryocyte-erythroid progenitor and share many regulators including the transcription factors GATA-1 and GFI-1B and signaling molecules such as JAK2 and STAT5. These lineages also share the distinction of being associated with rare, but aggressive malignancies that have very poor prognoses. In this review, we will briefly summarize features of normal development of red blood cells and megakaryocytes and also highlight events that lead to their leukemic transformation. It is clear that much more work needs to be done to improve our understanding of the unique biology of these leukemias and to pave the way for novel targeted therapeutics.Keywords
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