Primary Mediastinal Large B-Cell Lymphoma
Open Access
- 1 May 2006
- journal article
- review article
- Published by Oxford University Press (OUP) in The Oncologist
- Vol. 11 (5), 488-495
- https://doi.org/10.1634/theoncologist.11-5-488
Abstract
Learning Objectives: After completing this course, the reader will be able to: List the key clinical features of PMBCL.Discuss the literature on chemotherapy in PMBCL and the role of radiotherapy in PMBCL.Describe the pathologic features of PMBCL.Access and take the CME test online and receive 1 AMA PRA category 1 credit at CME.TheOncologist.comPrimary mediastinal large B-cell lymphoma represents a distinct entity with unique clinicopathologic features and a molecular gene-expression signature reminiscent of nodular sclerosis subtype of classical Hodgkin's lymphoma. Recent studies, including those using a refined molecular signature, suggest that the outcome is more favorable than that of diffuse large B-cell lymphoma. Using historical comparisons, dose-dense and dose-intensive regimens may be more effective than cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy; however, the impact of adding rituximab to these regimens and effect on outcome comparisons is unknown. Clinical trials exploring these questions in addition to the benefit of consolidative radiotherapy are necessary to definitively answer these questions.Keywords
This publication has 39 references indexed in Scilit:
- Introduction of Combined CHOP Plus Rituximab Therapy Dramatically Improved Outcome of Diffuse Large B-Cell Lymphoma in British ColumbiaJournal of Clinical Oncology, 2005
- Homozygous deletion of SOCS1 in primary mediastinal B-cell lymphoma detected by CGH to BAC microarraysLeukemia, 2005
- Mutational Analysis of IgVH and BCL-6 Genes Suggests Thymic B-cells Origin of Mediastinal (Thymic) B-cell LymphomaLeukemia & Lymphoma, 2004
- Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin LymphomaThe Journal of Experimental Medicine, 2003
- The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphomaBlood, 2003
- MAL Expression in Lymphoid Cells: Further Evidence for MAL as a Distinct Molecular Marker of Primary Mediastinal Large B-Cell LymphomasLaboratory Investigation, 2002
- Efficacy of an early intensification treatment integrating chemotherapy, autologous stem cell transplantation and radiotherapy for poor risk primary mediastinal large B cell lymphoma with sclerosisBone Marrow Transplantation, 2002
- Primary Mediastinal B-Cell Lymphoma with Sclerosis: Clinical and Therapeutic Evaluation of 22 PatientsLeukemia & Lymphoma, 1996
- Comparison of a Standard Regimen (CHOP) with Three Intensive Chemotherapy Regimens for Advanced Non-Hodgkin's LymphomaThe New England Journal of Medicine, 1993
- THE HUMAN THYMUS CONTAINS A NOVEL POPULATION OF B LYMPHOCYTESThe Lancet, 1987