Randomized clinical trial comparing side to end vs end to end techniques for colorectal anastomosis
- 7 October 2020
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in International Journal of Surgery
- Vol. 83, 220-229
- https://doi.org/10.1016/j.ijsu.2020.09.039
Abstract
BACKGROUND: Low anterior resection syndrome affects 60% to 90% of patients with anastomoses after colorectal resection. Consensus regarding the best anastomosis is lacking. OBJECTIVE: To compare outcomes after end-to-end versus side-to-end anastomoses. DESIGN: Randomized clinical trial. SETTINGS: University hospital (April 2016–October 2017). PATIENTS: Patients aged ≥18 years with rectal or sigmoid adenocarcinoma. INTERVENTIONS: Patients were randomized to undergo mechanical end-to-end or side-to-end (n=33) anastomosis after laparoscopic resection. MAIN OUTCOME MEASURES Primary outcome was to assess intestinal function (COREFO and LARS questionnaires) 12 months after surgery or ileostomy closure. Secondary outcomes were postoperative complications and intestinal function and quality of life (SF-36® questionnaire) at different time points after surgery or ileostomy closure. RESULTS: No significant differences in intestinal function were observed between the two groups 12 months after surgery. Subanalysis of low-mid rectum tumors with end-to-end anastomosis yielded better function at 12 months. Postoperative complications did not differ between the two groups (p=0.070), but reinterventions were more common in the side-to-end group (p=0.040). Multivariate analysis found neoadjuvant treatment was independently associated with intestinal dysfunction at 12 months (β=0.41, p=0.033, COREFO; β=0.41, p=0.024, LARS). CONCLUSIONS: End-to-end anastomosis yielded low rates of severe complications and reintervention, as well as better intestinal function at 12 months in the subgroup with tumors in the low-mid rectum. TRIAL REGISTRATION clinicaltrials.gov identifier: NCT02746224.Keywords
Funding Information
- Girona Biomedical Research Institute (IDIBGI), Girona, Spain
This publication has 32 references indexed in Scilit:
- Quality of life with or without sphincter preservation for rectal cancerColorectal Disease, 2019
- Low anterior resection syndrome after right‐ and left‐sided resections for colonic cancerBJS Open, 2018
- A quest for sphincter-saving surgery in ultralow rectal tumoursa single-centre cohort studyWorld Journal of Surgical Oncology, 2018
- Bowel dysfunction after sigmoid resection underestimated: Multicentre study on quality of life after surgery for carcinoma of the rectum and sigmoidEuropean Journal of Surgical Oncology, 2018
- Quality of life and anterior resection syndrome after surgery for mid to low rectal cancer: A cross-sectional studyEuropean Journal of Surgical Oncology, 2018
- Incidencia y caracterización del síndrome de resección anterior de recto mediante la utilización de la escala LARS (low anterior resection score)Cirugía Española, 2016
- Advances and Challenges in Treatment of Locally Advanced Rectal CancerJournal of Clinical Oncology, 2015
- Meta-analysis of reconstruction techniques after low anterior resection for rectal cancerBritish Journal of Surgery, 2015
- Bowel Function 14 Years After Preoperative Short-Course Radiotherapy and Total Mesorectal Excision for Rectal Cancer: Report of a Multicenter Randomized TrialClinical Colorectal Cancer, 2014
- Anterior resection syndromeThe Lancet Oncology, 2012