Sleep Apnea Is Associated with Cardiovascular Risk Factors among Kidney Transplant Patients
- 1 January 2010
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Journal of the American Society of Nephrology
- Vol. 5 (1), 125-132
- https://doi.org/10.2215/cjn.04030609
Abstract
Background and objectives: We assessed the prevalence of obstructive sleep apnea (OSA) and its clinical correlates in a large sample of patients who received a kidney transplant (Tx). We also compared the prevalence of the disorder between dialysis patients who were on the waiting list for a Tx (WL) and Tx patients. Design, setting, participants, & measurements: This was a cross-sectional study of 100 Tx and 50 WL patients who underwent one-night polysomnography (SLeep disorders Evaluation in Patients after kidney Transplantation [SLEPT] Study). Sociodemographic information and data about medication, comorbidity, and laboratory parameters were collected. Results: The prevalence of mild (apnea-hypopnea index [AHI] ≥5/h and versus 31%; P = 0.022). Despite taking significantly more antihypertensive drugs, the average systolic BP was still higher in patients with versus without OSA (147 ± 21 versus 139 ± 18 mmHg; P = 0.059). Conclusions: The prevalence of OSA is similar in Tx and WL patients and it may contribute to presence of hypertension in patients who receive a Tx.This publication has 40 references indexed in Scilit:
- Sleep Disordered Breathing in Renal Transplant PatientsAmerican Journal of Transplantation, 2009
- Improvement in Sleep Apnea during Nocturnal Peritoneal Dialysis Is Associated with Reduced Airway Congestion and Better Uremic ClearanceClinical Journal of the American Society of Nephrology, 2009
- Subjective and Objective Sleep Quality in Patients on Conventional Thrice-Weekly Hemodialysis: Comparison With Matched Controls From the Sleep Heart Health StudyAmerican Journal of Kidney Diseases, 2008
- Effect of Nocturnal Nasal Continuous Positive Airway Pressure on Blood Pressure in Obstructive Sleep ApneaHypertension, 2007
- Obstructive sleep apnoea inhibits the recovery of left ventricular function in patients with acute myocardial infarctionEuropean Heart Journal, 2006
- Body Composition Assessed by Impedance Changes Very Early with Declining Renal Graft FunctionNephron Physiology, 2006
- Obstructive Sleep Apnea as a Risk Factor for Stroke and DeathThe New England Journal of Medicine, 2005
- Reversal of sleep apnea hypopnea syndrome in end-stage renal disease after kidney transplantationAmerican Journal of Kidney Diseases, 1999
- Stroke risk profile: adjustment for antihypertensive medication. The Framingham Study.Stroke, 1994
- A new method of classifying prognostic comorbidity in longitudinal studies: Development and validationJournal of Chronic Diseases, 1987