Application of metabolomics in toxicity evaluation of traditional Chinese medicines
Open Access
- 4 December 2018
- journal article
- review article
- Published by Springer Science and Business Media LLC in Chinese Medicine
- Vol. 13 (1), 1-14
- https://doi.org/10.1186/s13020-018-0218-5
Abstract
Traditional Chinese medicines (TCM) have a long history of use because of its potential complementary therapy and fewer adverse effects. However, the toxicity and safety issues of TCM have drawn considerable attention in the past two decades. Metabolomics is an “omics” approach that aims to comprehensively analyze all metabolites in biological samples. In agreement with the holistic concept of TCM, metabolomics has shown great potential in efficacy and toxicity evaluation of TCM. Recently, a large amount of metabolomic researches have been devoted to exploring the mechanism of toxicity induced by TCM, such as hepatotoxicity, nephrotoxicity, and cardiotoxicity. In this paper, the application of metabolomics in toxicity evaluation of bioactive compounds, TCM extracts and TCM prescriptions are reviewed, and the potential problems and further perspectives for application of metabolomics in toxicological studies are also discussed.Keywords
Funding Information
- National Key Research and Development Program of China (2017YFC1701105, 2017YFC1701103)
- National Natural Science Foundation of China (81673569, 81803685)
- National Natural Science Foundation of China (81803697)
- National Modern Agricultural Industrial Park of China (NO. njf [2017] 110)
- Natural Science Foundation of Hebei Province (H2018205185, H2018423032)
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