Development and testing of a new measure of health status for clinical trials in heart failure
- 1 March 1989
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of General Internal Medicine
- Vol. 4 (2), 101-107
- https://doi.org/10.1007/bf02602348
Abstract
The authors developed a new measure of subjective health status for patients with heart failure. Eighty-eight patients with heart failure were asked about the impact of their condition on 123 items related to physical and emotional function. The most frequently chosen and important items were included in a 16-item Chronic Heart Failure Questionnaire (CHQ) that examines dyspnea during daily activities, fatigue, and emotional function. The CHQ was tested in a controlled trial of digoxin in heart failure patients in sinus rhythm. When administered serially to 25 patients in the run-in phase of the trial, the CHQ proved reproducible. Subsequently, CHQ results distinguished those who reported improvement or deterioration from those who did not. The CHQ showed moderate correlations with patient global ratings, walk test scores, and clinical assessments of heart failure. The authors conclude that the CHQ may be useful for measuring health status in clinical trials in heart failure.Keywords
This publication has 18 references indexed in Scilit:
- Measuring change over time: Assessing the usefulness of evaluative instrumentsJournal of Chronic Diseases, 1987
- Effects of Enalapril on Mortality in Severe Congestive Heart FailureThe New England Journal of Medicine, 1987
- Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart FailureThe New England Journal of Medicine, 1986
- Measuring disease-specific quality of life in clinical trials.1986
- How should we measure function in patients with chronic heart and lung disease?Journal of Chronic Diseases, 1985
- Methodologic problems in clinical trials in heart failureJournal of Chronic Diseases, 1985
- A methodological framework for assessing health indicesJournal of Chronic Diseases, 1985
- The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure.1985
- Oral amrinone for the treatment of chronic congestive heart failure: Results of a multicenter randomized double-blind and placebo-controlled withdrawal studyJournal of the American College of Cardiology, 1984
- Enalapril in patients with chronic heart failure: a placebo-controlled, randomized, double-blind study.Circulation, 1984