The New B7s: Playing a Pivotal Role in Tumor Immunity
- 1 April 2007
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Immunotherapy
- Vol. 30 (3), 251-260
- https://doi.org/10.1097/cji.0b013e31802e085a
Abstract
B7-H1, B7-DC, B7-H2, B7-H3, and B7-H4, all new additions to the B7 family, here termed “the new B7s,” are emerging as important tools in directing immune function; each with unique, yet often overlapping functions. Clearly, each B7 molecule has developed its own indispensable niche in the immune system. The expression of both stimulatory and inhibitory B7 molecules seems to play an essential role in regulating the immune response to transformed cells through a variety of mechanisms. As specific niches of B7 family members continue to be dissected, their diagnostic and therapeutic potential becomes ever more apparent. In this review, we will discuss the role of the new B7s in activation and inhibition of antitumor immune responses, their prospects in diagnostics, and also potential and developing immunotherapy protocols.Keywords
This publication has 113 references indexed in Scilit:
- B7-H4 expression in renal cell carcinoma and tumor vasculature: Associations with cancer progression and survivalProceedings of the National Academy of Sciences of the United States of America, 2006
- No evidence for dualism in function and receptors: PD‐L2/B7‐DC is an inhibitory regulator of human T cell activationEuropean Journal of Immunology, 2006
- Adoptive immunotherapy for cancer: building on successNature Reviews Immunology, 2006
- Tissue expression of PD-L1 mediates peripheral T cell toleranceThe Journal of Experimental Medicine, 2006
- B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinomaThe Journal of Experimental Medicine, 2006
- The B7-H1 (PD-L1) T Lymphocyte-Inhibitory Molecule Is Expressed in Breast Cancer Patients with Infiltrating Ductal Carcinoma: Correlation with Important High-Risk Prognostic FactorsNeoplasia, 2006
- Interferon regulatory factor‐1 is prerequisite to the constitutive expression and IFN‐γ‐induced upregulation of B7‐H1 (CD274)FEBS Letters, 2006
- Expression of Functional B7-H2 and B7.2 Costimulatory Molecules and Their Prognostic Implications inDe novoAcute Myeloid LeukemiaClinical Cancer Research, 2005
- In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responsesThe Journal of Experimental Medicine, 2005
- Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunityNature Reviews Immunology, 2004