The Na+/Ca2+ Exchange Molecule
- 1 November 2002
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 976 (1), 1-10
- https://doi.org/10.1111/j.1749-6632.2002.tb04708.x
Abstract
An overview of the molecular physiology of the Na(+)/Ca(2+) exchanger is presented. This includes information on the variety of exchangers that have been described and their regulatory properties. Molecular insight is most detailed for the cardiac Na(+)/Ca(2+) exchanger (NCX1). Parts of the NCS1 molecule involved in regulation and ion transport have been elucidated, and initial information on the topology and structure is available.Keywords
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