Determination of biological activity of adinazolam and its metabolites
- 1 August 1984
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 36 (8), 546-548
- https://doi.org/10.1111/j.2042-7158.1984.tb04449.x
Abstract
Adinazolam and its metabolites inhibit [3H]flunitrazepam binding in-vitro. The binding affinities of these compounds is significantly enhanced in the presence of 10-5 M muscimol, indicating that both adinazolam and its metabolites are benzodiazepine agonists. In-vivo metabolism of adinazolam results in the formation of active metabolites.Keywords
This publication has 6 references indexed in Scilit:
- An in vitro binding assay which differentiates benzodiazepine ‘agonists’ and ‘antagonists’European Journal of Pharmacology, 1982
- Determination of biological activity of alprazolam, triazolam and their metabolitesJournal of Pharmacy and Pharmacology, 1982
- GABA reduces binding of 3H-methyl β-carboline-3-carboxylate to brain benzodiazepine receptorsNature, 1981
- 1-(Aminoalkyl)-6-aryl-4H-s-triazolo[4,3-a][1,4]benzodiazepines with antianxiety and antidepressant activityJournal of Medicinal Chemistry, 1980
- Partial agonists for brain GABA/benzodiazepine receptor complexNature, 1979
- Pharmacology of some metabolites of triazolam, alprazolam, and diazepam prepared by a simple, one-step oxidation of benzodiazepinesJournal of Medicinal Chemistry, 1978