Flavonoids in prevention of diseases with respect to modulation of Ca-pump function
Open Access
- 1 January 2011
- journal article
- Published by Walter de Gruyter GmbH in Interdisciplinary Toxicology
- Vol. 4 (3), 114-124
- https://doi.org/10.2478/v10102-011-0019-5
Abstract
Flavonoids, natural phenolic compounds, are known as agents with strong antioxidant properties. In many diseases associated with oxidative/nitrosative stress and aging they provide multiple biological health benefits. Ca2+-ATPases belong to the main calcium regulating proteins involved in the balance of calcium homeostasis, which is impaired in oxidative/nitrosative stress and related diseases or aging. The mechanisms of Ca2+-ATPases dysfunction are discussed, focusing on cystein oxidation and tyrosine nitration. Flavonoids act not only as antioxidants but are also able to bind directly to Ca2+-ATPases, thus changing their conformation, which results in modulation of enzyme activity.Keywords
This publication has 81 references indexed in Scilit:
- Tea flavonoids and cardiovascular healthMolecular Aspects of Medicine, 2010
- Short Communication: Oxidative Posttranslational Modifications Mediate Decreased SERCA Activity and Myocyte Dysfunction in Gαq-Overexpressing MiceCirculation Research, 2010
- Targeting the redox regulation of SERCA in vascular physiology and diseaseCurrent Opinion in Pharmacology, 2010
- Cysteine-674 oxidation and degradation of sarcoplasmic reticulum Ca2+ ATPase in diabetic pig aortaFree Radical Biology & Medicine, 2008
- Nitric Oxide and Peroxynitrite in Health and DiseasePhysiological Reviews, 2007
- The Antioxidant Edaravone Attenuates Pressure Overload–Induced Left Ventricular HypertrophyHypertension, 2005
- Ca2+ homeostasis and apoptotic resistance of neuroendocrine-differentiated prostate cancer cellsCell Death & Differentiation, 2003
- The Nucleotide-Binding Site of the Sarcoplasmic Reticulum Ca−ATPase Is Conformationally Altered in Aged Skeletal Muscle†Biochemistry, 1999
- Structure-antioxidant activity relationships of flavonoids and phenolic acidsFree Radical Biology & Medicine, 1996
- Derivative spectroscopy of tryptophan fluorescence used to study conformational transitions in the (Ca2+ + Mg2+)-adenosine triphosphatase of sarcoplasmic reticulumBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1986