Longitudinal assessment of anxiety, depression, and fatigue in people with multiple sclerosis
- 1 March 2009
- journal article
- Published by Wiley in Psychology and Psychotherapy: Theory, Research and Practice
- Vol. 82 (1), 41-56
- https://doi.org/10.1348/147608308x345614
Abstract
No longitudinal studies have concurrently evaluated predictors of anxiety, depression, and fatigue in people with multiple sclerosis (PwMS). This study determined factors that best predicted anxiety, depression, and fatigue in MS patients from a large pool of disease, cognitive, life-event stressor (LES), psychosocial, life-style, and demographic factors. A 2-year prospective longitudinal study evaluated predictors of psychological distress and fatigue in PwMS. One hundred and one consecutive participants with MS were recruited from two MS clinics in Sydney, Australia. LES, anxiety, depression, and fatigue were assessed at baseline and at 3-monthly intervals for 2-years. Disease, cognitive, demographic, psychosocial, and life-style factors were assessed at baseline. Patient-reported relapses were recorded and corroborated by neurologists or evaluated against accepted relapse criteria. Depression strongly predicted anxiety and fatigue, and anxiety and fatigue strongly predicted later depression. Psychological distress (i.e. anxiety, depression) was also predicted by a combination of unhealthy behaviours (e.g. drug use, smoking, no exercise, or relaxation) and psychological factors (e.g. low optimism, avoidance coping), similar to the results of community-based studies. However, state-anxiety and fatigue were also predicted by immunotherapy status, and fatigue was also predicted by LES and demographics. These results suggest that similar factors might underpin psychological distress and fatigue in MS patients and community-well samples, although MS treatment factors may also be important. These results might assist clinicians in determining which MS patients are at greatest risk of developing anxiety, depression, or fatigue.Keywords
This publication has 42 references indexed in Scilit:
- A longitudinal study of variations in and predictors of fatigue in multiple sclerosisJournal of Neurology, Neurosurgery & Psychiatry, 2008
- Longitudinal course of depression symptoms in multiple sclerosisJournal of Neurology, Neurosurgery & Psychiatry, 2006
- Fatigue in multiple sclerosis: relationship to depression, disability, and disease patternMultiple Sclerosis Journal, 2000
- Psychological functioning in primary progressive versus secondary progressive multiple sclerosisPsychology and Psychotherapy: Theory, Research and Practice, 1998
- The structure of negative emotional states: Comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety InventoriesBehaviour Research and Therapy, 1995
- A Test of the Relationship Between Health Locus of Control and the Course of Multiple SclerosisRehabilitation Nursing Journal, 1991
- A Brief Measure of Social Support: Practical and Theoretical ImplicationsJournal of Social and Personal Relationships, 1987
- Rating neurologic impairment in multiple sclerosisNeurology, 1983
- New diagnostic criteria for multiple sclerosis: Guidelines for research protocolsAnnals of Neurology, 1983
- Comparison of transcendental meditation and progressive relaxation in reducing anxiety.BMJ, 1978