Hax1 regulates neutrophil adhesion and motility through RhoA
Open Access
- 25 April 2011
- journal article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 193 (3), 465-473
- https://doi.org/10.1083/jcb.201010143
Abstract
Loss of Hax1, which is associated with a severe congenital neutropenia syndrome, impairs neutrophil uropod detachment and directed migration.Keywords
This publication has 28 references indexed in Scilit:
- An arrayed high-content chemotaxis assay for patient diagnosisIntegrative Biology, 2010
- Live imaging of neutrophil motility in a zebrafish model of WHIM syndromeBlood, 2010
- Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migrationThe Journal of cell biology, 2010
- Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1Nature, 2010
- Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live ZebrafishDevelopmental Cell, 2010
- WHIM syndrome: congenital immune deficiency diseaseCurrent Opinion in Hematology, 2009
- The PCH Family Member Proline-Serine-Threonine Phosphatase–interacting Protein 1 Targets to the Leukocyte Uropod and Regulates Directed Cell MigrationMolecular Biology of the Cell, 2008
- A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironmentLab on a Chip, 2008
- Type Iγ PIP Kinase Is a Novel Uropod Component that Regulates Rear Retraction during Neutrophil ChemotaxisMolecular Biology of the Cell, 2007
- Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerizationBiochemical Journal, 2003