Induction of bone, cartilage and hemopoietic tissue by subcutaneously implanted tissue diaphragms

Abstract

The subcutaneous implantation of appropriate tissue diaphragms (short, broad glass cylinders) rather regularly induces the formation of bones provided with marrow cavities and junction cartilage plates, in the rat. Bone formation, unlike the development of hemopoietic tissue, can be prevented, under these circumstances, by topical blockade of the phagocyte system with carbon particles. The role of nonspecific topical stress factors, in the induction of such highly specific structural transformations, has been discussed.