System for Nasopharyngeal Carcinoma: Comparison of Fourth and Fifth Editions of UICC TNM Classification
- 1 December 2000
- journal article
- research article
- Published by SAGE Publications in Annals of Otology, Rhinology & Laryngology
- Vol. 109 (12), 1125-1129
- https://doi.org/10.1177/000348940010901208
Abstract
Staging nasopharyngeal carcinoma (NPC) by the UICC 4th-edition TNM classification system (the old system) did not give an accurate prognosis because of the uneven distribution of patients in each stage. This system was revised in 1997 (the new system). To evaluate the performance of the new system, 35 patients with NPC who had been staged by the old system were restaged according to the new system. Restaging of the patients resulted in an overall “downstaging.” Differences in the overall survival rates of the early group (stages I, II, III), stage IVA, stage IVB, and stage IVC patients were statistically significant (75%, 48%, 74%, and 0%, respectively; p = .01). T4 was a significant factor of poor outcome (hazard rate, 2.932; 95% CI, 1.667 to 8.545), whereas N3 was not (hazard rate, 0.858; 95% CI, 0.281 to 2.618). The new staging system is more useful than the old system.Keywords
This publication has 5 references indexed in Scilit:
- A comparison of staging systems for nasopharyngeal carcinomaCancer, 1998
- The expression of matrix metalloproteinase 9 is enhanced by Epstein–Barr virus latent membrane protein 1Proceedings of the National Academy of Sciences, 1998
- Study on new stage classification of nasopharyngeal carcinoma.Japanese jornal of Head and Neck Cancer, 1998
- The prognostic significance of parapharyngeal tumour involvement in nasopharyngeal carcinomaRadiotherapy and Oncology, 1996
- A comparison of Ho's, international union against cancer, and American joint committee stage classifications for nasopharyngeal carcinomaCancer, 1991