RSRC1 SUMOylation enhances SUMOylation and inhibits transcriptional activity of estrogen receptor β
- 30 April 2015
- journal article
- Published by Wiley in FEBS Letters
- Vol. 589 (13), 1476-1484
- https://doi.org/10.1016/j.febslet.2015.04.035
Abstract
The transcription factor estrogen receptor β (ERβ) plays roles in the central nervous, endocrine, cardiovascular, and immune systems. ERβ can be SUMOylated. However, the underlying mechanism remains unclear. Here, we show that RSRC1/SRrp53 interacts with ERβ and SUMOylation of RSRC1 is required for regulation of PIAS1-mediated ERβ SUMOylation. RSRC1 promotes ERβ SUMOylation through enhanced interaction between ERβ and PIAS1. RSRC1 represses ERβ transcriptional activity through regulation of ERβ SUMOylation. By establishing RSRC1 as a novel cofactor for SUMOylation, our data provide insight into regulation of ERβ SUMOylation and indicate that SUMOylation of one protein can regulate another protein SUMOylation.Funding Information
- China Major State Basic Research Development Program (2011CB504202, 2012CB945100)
- National Natural Science Foundation (81330053, 81272913, 31200565)
- Beijing Natural Science Foundation (5132027)
- Beijing Nova Program (Z131102000413034)
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