Surgically implanted and non‐invasive vagus nerve stimulation: a review of efficacy, safety and tolerability
Top Cited Papers
Open Access
- 23 January 2015
- journal article
- review article
- Published by Wiley in European Journal of Neurology
- Vol. 22 (9), 1260-1268
- https://doi.org/10.1111/ene.12629
Abstract
Vagus nerve stimulation (VNS) is effective in refractory epilepsy and depression and is being investigated in heart failure, headache, gastric motility disorders and asthma. The first VNS device required surgical implantation of electrodes and a stimulator. Adverse events (AEs) are generally associated with implantation or continuous on−off stimulation. Infection is the most serious implantation‐associated AE. Bradycardia and asystole have also been described during implantation, as has vocal cord paresis, which can last up to 6 months and depends on surgical skill and experience. The most frequent stimulation‐associated AEs include voice alteration, paresthesia, cough, headache, dyspnea, pharyngitis and pain, which may require a decrease in stimulation strength or intermittent or permanent device deactivation. Newer non‐invasive VNS delivery systems do not require surgery and permit patient‐administered stimulation on demand. These non‐invasive VNS systems improve the safety and tolerability of VNS, making it more accessible and facilitating further investigations across a wider range of uses.Keywords
This publication has 53 references indexed in Scilit:
- Answer to comment on “sleep quality, arousal and pain thresholds in migraineurs: a blinded controlled polysomnographic study”The Journal of Headache and Pain, 2013
- Evoked Pain Analgesia in Chronic Pelvic Pain Patients Using Respiratory-Gated Auricular Vagal Afferent Nerve StimulationPain Medicine, 2012
- Transcutaneous vagus nerve stimulation (t‐VNS) in pharmacoresistant epilepsies: A proof of concept trialEpilepsia, 2012
- Vagus nerve stimulation for epilepsy: A review of the peripheral mechanismsSurgical Neurology International, 2012
- Electrical vagus nerve stimulation for the treatment of chronic heart failureCleveland Clinic Journal of Medicine, 2011
- Ventricular asystole during vagal nerve stimulationEpilepsia, 2009
- Vagal Nerve Stimulation: Overview and Implications for AnesthesiologistsAnesthesia & Analgesia, 2006
- Vagus Nerve Stimulation in Patients With Alzheimer's DiseaseThe Journal of Clinical Psychiatry, 2006
- A Pilot Study of Mood in Epilepsy Patients Treated with Vagus Nerve StimulationEpilepsy & Behavior, 2000
- Feasibility and Safety of Vagal Stimulation In Monkey ModelEpilepsia, 1990