Time-gated Cherenkov emission spectroscopy from linear accelerator irradiation of tissue phantoms
- 26 March 2012
- journal article
- Published by Optica Publishing Group in Optics Letters
- Vol. 37 (7), 1193-5
- https://doi.org/10.1364/ol.37.001193
Abstract
Radiation from a linear accelerator induces Cherenkov emission in tissue, which has recently been shown to produce biochemical spectral signatures that can be interpreted to estimate tissue hemoglobin and oxygen saturation or molecular fluorescence from reporters. The Cherenkov optical light levels are in the range of 10(-6) to 10(-9) W/cm2, which limits the practical utility of the signal in routine radiation therapy monitoring. However, due to the fact that the radiation is pulsed, gated-acquisition of the signal allows detection in the presence of ambient lighting, as is demonstrated here. This observation has the potential to significantly increase the value of Cherenkov emission spectroscopy during radiation therapy to monitor tissue molecular events.Funding Information
- National Institutes of Health (R01 CA120368, R01 CA109558)
This publication has 12 references indexed in Scilit:
- In vivo Cerenkov luminescence imaging: a new tool for molecular imagingPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2011
- Multimodal Imaging with 18F-FDG PET and Cerenkov Luminescence Imaging After MLN4924 Treatment in a Human Lymphoma Xenograft ModelJournal of Nuclear Medicine, 2011
- Cerenkov emission induced by external beam radiation stimulates molecular fluorescenceMedical Physics, 2011
- Cerenkov Luminescence Imaging of Medical IsotopesJournal of Nuclear Medicine, 2010
- Cerenkov luminescence tomography for small-animal imagingOptics Letters, 2010
- Molecular Optical Imaging with Radioactive ProbesPLOS ONE, 2010
- Cerenkov radiation allowsin vivooptical imaging of positron emitting radiotracersPhysics in Medicine & Biology, 2009
- Optical imaging of Cerenkov light generation from positron-emitting radiotracersPhysics in Medicine & Biology, 2009
- Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center studyRadiotherapy and Oncology, 2005
- Visible Radiation Produced by Electrons Moving in a Medium with Velocities Exceeding that of LightPhysical Review B, 1937