Time Dependence of Elastic Recovery for Characterization of Tableting Materials
- 25 January 2001
- journal article
- Published by Taylor & Francis Ltd in Pharmaceutical Development and Technology
- Vol. 6 (1), 61-70
- https://doi.org/10.1081/pdt-100000014
Abstract
The purpose of this study was to complete information on elastic recovery during a compression cycle by measuring the expansion of the tablet after ejection, and thus, to measure the whole recovery process, which means the time dependency of elastic recovery. Two methods were applied: manual measurement by a micrometer screw, and a continuous measurement by thermomechanical analysis, always at a constant temperature and humidity. Elastic recovery of the tablet continued after ejection from the die, and the amount of expansion was different for the tableting materials used. The results showed that expansion continued for most of the materials over several days, until a steady state of the tablet and its physical properties was reached. The extent and the profiles of the elastic recovery curves were different for the tableting materials dicalcium phosphate dihydrate, carrageenan, microcrystalline cellulose, cellulose acetate, hydroxypropyl methylcellulose and theophylline monohydrate. There were slight differences between both the methods used. The profiles of the materials could be related to some properties of the materials.Keywords
This publication has 19 references indexed in Scilit:
- Matrix Tablets of Carrageenans. I. A Compaction Study*Drug Development and Industrial Pharmacy, 1999
- Effect of Relative Humidity During Tabletting on Matrix Formation of Hydrocolloids: Densification Behavior of Cellulose EthersPharmaceutical Development and Technology, 1998
- Dehydration of theophylline monohydrate—a two step processInternational Journal of Pharmaceutics, 1997
- Indices of Tableting Performance for Acrylic Resin Polymers with Plastic and Brittle DrugsDrug Development and Industrial Pharmacy, 1993
- Time-dependent deformation of some direct compression excipientsJournal of Pharmacy and Pharmacology, 1978
- Crystallinity and physical characteristics of microcrystalline cellulose.CHEMICAL & PHARMACEUTICAL BULLETIN, 1977
- Crystallinity and physical characteristics of microcrystalline cellulose. II. Fine structure of ground microcrystalline cellulose.CHEMICAL & PHARMACEUTICAL BULLETIN, 1977
- The influence of the moisture content of the fibrous support of a nasal inhaler upon the concentration of drug in the air streamJournal of Pharmacy and Pharmacology, 1972
- Thermodynamic Effects in the Compression of SolidsJournal of Pharmaceutical Sciences, 1968
- Physics of Tablet Compression XV. Thermodynamic and Kinetic Aspects of Adhesion Under PressureJournal of Pharmaceutical Sciences, 1968