Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor
- 13 May 1994
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 264 (5161), 965-968
- https://doi.org/10.1126/science.8178155
Abstract
A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.Keywords
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