SH2-B Promotes Insulin Receptor Substrate 1 (IRS1)- and IRS2-mediated Activation of the Phosphatidylinositol 3-Kinase Pathway in Response to Leptin
Open Access
- 1 October 2004
- journal article
- Published by Elsevier BV
- Vol. 279 (42), 43684-43691
- https://doi.org/10.1074/jbc.m408495200
Abstract
No abstract availableThis publication has 52 references indexed in Scilit:
- STAT3 signalling is required for leptin regulation of energy balance but not reproductionNature, 2003
- SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2Journal of Biological Chemistry, 2002
- Short-Term Leptin-Dependent Inhibition of Hepatic Gluconeogenesis Is Mediated by Insulin Receptor Substrate-2Molecular Endocrinology, 2002
- Four PSM/SH2-B Alternative Splice Variants and Their Differential Roles in MitogenesisPublished by Elsevier BV ,2001
- SH2-B and APS Are Multimeric Adapters That Augment TrkA SignalingMolecular and Cellular Biology, 2001
- Mechanism of Phosphorylation of Protein Kinase B/Akt by a Constitutively Active 3-Phosphoinositide-dependent Protein Kinase-1Published by Elsevier BV ,2000
- Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin ReceptorPublished by Elsevier BV ,1997
- Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db MiceCell, 1996
- Abnormal splicing of the leptin receptor in diabetic miceNature, 1996
- Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model.JCI Insight, 1993