The HLA‐DQ(α1*0102, β1*0602) heterodimer may confer susceptibility to multiple sclerosis in the absence of the HLA‐DR(α1*01, β1*1501) heterodimer
- 1 July 1997
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 50 (1), 15-22
- https://doi.org/10.1111/j.1399-0039.1997.tb02828.x
Abstract
The frequencies of DR2, DQ6-related DRB1, DQA1, DQB1 haplotypes were compared in 181 multiple sclerosis patients and 294 controls in Norway. All individuals carried either DR2 or DQ6, i.e., the DQ(α1*0102, β1*0602) heterodimer. The DR(α1*01,β1*1501) and the DQ(α1*O102,β1*O602) heterodimers were carried by 171 of the patients (94%) and 289 (98%) of the controls. Seven of the patients and one of the controls carried the DQ(α1*0102, β1*0603) heterodimer together with the DR(α1*01, β1* 1501) heterodimer. Two patients carried the DQ(α1*0102, β1*O602) heterodimer in the absence of the DR(α1*O1, β1*1501) heterodimer. The DR(α1*01, β1*1501) heterodimer was not observed in the absence of the DQ(α1*0102, β1*O602) heterodimer or the DQ(α1*O102, β1*0603) heterodimer, neither in the patients nor in therols. Our findings indicate that the genes encoding the DQ(α1*0102,β1*0602) heterodimer may confer susceptibility to developing multiple sclerosis in the absence of the DRB 1* 1501 allele.Keywords
This publication has 33 references indexed in Scilit:
- Nomenclature for factors of the HLA system, 1994Human Immunology, 1994
- Asian Indian HLA-DR2-, DR4-, and DR52-related DR-DQ genotypes analyzed by polymerase chain reaction based nonradioactive oligonucleotide typing unique haplotypes and a novel DR4 subtypeHuman Immunology, 1994
- Association of susceptibility to multiple sclerosis in Sweden with HLA class II DRB1 and DQB1 allelesHuman Immunology, 1994
- A deletion in the second exon of an HLA-DRB1 Allele found in a DR2-negative narcolepsy patientHuman Immunology, 1993
- Evolutionary relationships of HLA-DR8 alleles and description of a new subtype (DRB1∗0806) in the Algerian populationHuman Immunology, 1993
- Characterization of an HLA-DR15 DQ5 haplotype found in the Spanish caucasoid populationHuman Immunology, 1992
- Extensive study of DRB, DQA, and DQB gene polymorphism in 23 DR2-positive, insulin-dependent diabetes mellitus patientsHuman Immunology, 1992
- Increasing complexity of HLA-DR2 as detected by serology and oligonucleotide typingHuman Immunology, 1991
- Patients with multiple sclerosis carry DQB1 genes which encode shared polymorphic amino acid sequencesHuman Immunology, 1989
- New diagnostic criteria for multiple sclerosis: Guidelines for research protocolsAnnals of Neurology, 1983