Cognitive change and the APOE ɛ4 allele
- 29 August 2002
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 418 (6901), 932
- https://doi.org/10.1038/418932a
Abstract
There is a marked variation in whether people retain sufficient cognitive function to maintain their quality of life and independence in old age, even among those without dementia, so it would be valuable to identify the determinants of normal age-related cognitive change1,2. We have retested non-demented 80-year-olds who were participants in the Scottish Mental Survey of 1932, and find that the variation in their non-pathological cognitive change from age 11 to 80 is related to their apolipoprotein E (APOE) genotype. This effect of the APOE ɛ4 allele on normal cognitive ageing may be mediated by a mechanism that is at least partly independent of its predisposing effect towards Alzheimer's disease.Keywords
This publication has 8 references indexed in Scilit:
- Apolipoprotein E: Far More Than a Lipid Transport ProteinAnnual Review of Genomics and Human Genetics, 2000
- APOE-ε4 count predicts age when prevalence of AD increases,then declinesNeurology, 2000
- Education, Activity, Health, Blood Pressure and Apolipoprotein E as Predictors of Cognitive Change in Old Age: A ReviewGerontology, 2000
- The Stability of Individual Differences in Mental Ability from Childhood to Old Age: Follow-up of the 1932 Scottish Mental SurveyIntelligence, 2000
- Risk Estimates of Dementia by Apolipoprotein E Genotypes From a Population-Based Incidence Study: The Rotterdam StudyArchives of Neurology, 1998
- Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer diseaseNature Genetics, 1994
- Apolipoprotein E genotyping by one-stage PCRThe Lancet, 1991
- Effects of apoprotein E polymorphism on serum lipoprotein concentration.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1985