Anti‐viral and anti‐bacterial activities of an extract of blackcurrants (Ribes nigrum L.)
Open Access
- 18 September 2012
- journal article
- research article
- Published by Wiley in Microbiology and Immunology
- Vol. 56 (12), 805-809
- https://doi.org/10.1111/j.1348-0421.2012.00510.x
Abstract
The inhibitory effects of an extract of the blackcurrant (Ribes nigrum L.) against pathogens associated with oral, nasopharyngeal and upper respiratory infectious diseases; namely respiratory syncytial virus (RSV), influenza virus A and B (IFV-A and IFV-B), adenovirus (AdV), herpes simplex virus type 1, Haemophilus influenzae type B, Streptococcus pneumoniae and Streptococcus mutans, were investigated. Less than 1% concentration of extract of blackcurrant inhibited replication of RSV, IFV-A and -B and HSV-1 by over 50% and a 10% extract inhibited adsorption of these viruses onto the cell surface by over 95%. The effects on AdV were much less pronounced; the half minimal inhibitory concentration of AdV replication was 2.54 ± 0.26, and a 10% concentration of the extract inhibited AdV adsorption on the cell surface by 72.9 ± 3.4%. The antibacterial activities of the blackcurrant were evaluated based on its efficacy as a disinfectant. A 10% extract disinfected 99.8% of H. Influenzae type B and 78.9% of S. pneumoniae in 10 min, but had no demonstrable effect against S. mutans. The blackcurrant extract still showed antiviral and antibacterial activities after the pH had been made neutral with sodium hydroxide, suggesting that these activities are not the result of acidic reactions or of components precipitated at a neutral pH. These findings demonstrate the potential of blackcurrant extract as a functional food for oral care.Keywords
This publication has 26 references indexed in Scilit:
- Cranberry and Urinary Tract InfectionsDrugs, 2009
- Cranberry and blueberry: Evidence for protective effects against cancer and vascular diseasesMolecular Nutrition & Food Research, 2007
- Evidences of the cardioprotective potential of fruits: The case of cranberriesMolecular Nutrition & Food Research, 2007
- Cranberry cocktail juice, cranberry concentrates, and proanthocyanidins reduce reovirus infectivity titers in African green monkey kidney epithelial cell culturesMolecular Nutrition & Food Research, 2007
- Antiviral effects on bacteriophages and rotavirus by cranberry juicePhytomedicine, 2007
- Prevention of Nonspecific Bacterial Cell Adhesion in Immunoassays by Use of Cranberry JuiceAnalytical Chemistry, 2005
- Cranberry juice constituents affect influenza virus adhesion and infectivityAntiviral Research, 2005
- Inhibition ofHelicobacter pyloriAdhesion to Human Gastric Mucus by a High-Molecular-Weight Constituent of Cranberry JuiceCritical Reviews in Food Science and Nutrition, 2002
- A high molecular mass constituent of cranberry juice inhibitsHelicobacter pyloriadhesion to human gastric mucusFEMS Immunology & Medical Microbiology, 2000
- Inhibitory activity of cranberry juice on adherence of type 1 and type P fimbriated Escherichia coli to eucaryotic cellsAntimicrobial Agents and Chemotherapy, 1989