The research aims to analyze the density of mud clams Anodintia edentula Linnaeus, 1758 relation to environmental parameters, covering organic material content and composition of sediment in Muna regency. Research carried out in coastal Lambiku and Tobea island. The sample collection begins in March until May 2011, intervals collection example once a month for three months. A collection of mud clams example in a plot trasek (Line Transect Plot) is determined (purposive sampling). A plot observation based on three categories, Plot I near coast, Plot II the transition and Plot III far from the beach, intervals 50m each a plot observation. Analysis data the density use Krebs (1978) formula, relations of density and environmental parameters use corelation and descriptif analysis. The research results show that the density is different of mud clams between Tobea island and coastal Lambiku. The density of mud clams on the Tobea island have higher is 33 ind m-2 or 29-40 ind m-2. While density of mud clams in coast Lambiku is 10 ind m-2 or 8-11 ind m-2. The density of mud clams far from the beach between the coastal areas relatively different. While composition sediment and the organic matter on Tobea island and coastal Lambiku relatively is the same. Phosphates and sulphur concentration on the Tobea island each of 13,90 ppm and 15,76 ppm. Phosphates and sulphur concentration in coastal Lambiku each of 14,55 ppm and 17,01 ppm. Phosphate and sulfur concentrate far from shore show organic material content of sulphur and phosphates is high with density mud clams.