Role of CD4+CD25high+FOXP3+Regulatory T Cells in Psoriasis
Open Access
- 1 January 2010
- journal article
- Published by Korean Dermatological Association and The Korean Society for Investigative Dermatology in Annals of Dermatology
- Vol. 22 (4), 397-403
- https://doi.org/10.5021/ad.2010.22.4.397
Abstract
CD4(+)CD25(high+)regulatory T cells (Tregs) are considered to be of vital importance for maintaining immunologic self-tolerance and preventing autoimmune diseases. These cells have been found to be deficient in skin lesions and in the peripheral blood of patients with psoriasis. To investigate the role of Tregs in the pathogenesis of psoriasis and to evaluate the changes in Tregs in relation to the severity and the clinical course of psoriasis. Immunohistochemistry (CD3, 4, 8, 79 and FOXP3) was performed in 22 psoriatic patients compared to 5 normal controls. Flow cytometry (CD3, 4, 8, 25 and FOXP3) was performed in 18 psoriatic patients and 8 normal volunteers and reverse transcriptase polymerase chain reaction (foxp3 mRNA) was performed in 8 psoriasis patients. An increase in the FOXP3(+) cell fraction was detected in the lesional psoriatic skin irrespective of the severity of psoriasis as compared with the normal skin. However, a decrease in FOXP3(+) cells was observed in the samples obtained from psoriasis of 'acute course'. FOXP3(+) Treg populations in the blood of the 'acute course' psoriasis was not different compared to that of 'chronic course' psoriasis and normal controls. The deficiency of FOXP3(+) Tregs in the lesional psoriatic skin might be responsible for the exacerbation of psoriasis.Keywords
This publication has 19 references indexed in Scilit:
- Identification of Lesional CD4+ CD25+ Foxp3+ Regulatory T Cells in PsoriasisDermatology, 2006
- CD4+CD25+ REGULATORY T CELLS IN HEALTH AND DISEASEClinical and Experimental Pharmacology and Physiology, 2006
- Type I Regulatory T Cells in Autoimmunity and Inflammatory DiseasesInternational Archives of Allergy and Immunology, 2006
- Regulatory T cells, tumour immunity and immunotherapyNature Reviews Immunology, 2006
- Memory effector (CD45RO+) and cytotoxic (CD8+) T cells appear early in the margin zone of spreading psoriatic lesions in contrast to cells expressing natural killer receptors, which appear lateBritish Journal of Dermatology, 2004
- Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 The Journal of Experimental Medicine, 2003
- Immune regulation by CD4+CD25+ regulatory T cells: implications for transplantation toleranceTransplant Immunology, 2003
- Expression of the integrin αEβ7identifies unique subsets of CD25+as well as CD25−regulatory T cellsProceedings of the National Academy of Sciences of the United States of America, 2002
- CD4+CD25+ Immunoregulatory T CellsImmunity, 2002
- Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-toleranceNature Immunology, 2002