Transconjunctival Revision With Mitomycin-C Following Failed Trabeculectomy
- 1 July 2016
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Glaucoma
- Vol. 25 (7), 618-622
- https://doi.org/10.1097/ijg.0000000000000408
Abstract
Purpose: To evaluate the efficacy of transconjunctival revision (TCR) with mitomycin-C (MMC) following failed trabeculectomy. Materials and Methods: The medical records of 27 patients (27 eyes) who underwent TCR with subconjunctival injection of MMC by a single surgeon between September 2001 and August 2013 were retrospectively reviewed. The same surgical protocol was followed for all patients. Revision was performed using a microvitreoretinal blade through a small conjunctival incision. Main outcome measures included visual acuity, intraocular pressure (IOP), and number of glaucoma medications. Failure was defined as an IOP14 mm Hg, loss of light perception, or need for additional glaucoma surgery. Results: Mean interval between trabeculectomy and TCR was 56.4±57.2 months. Mean preoperative IOP was 21.9±6.8 mm Hg using 4.0±1.2 glaucoma medications. Fifteen (55.6%) patients met success criteria. At most recent follow-up, mean IOP and number of glaucoma medications for successful patients were 9.7±3.8 mm Hg and 0.6±1.1, respectively. Kaplan-Meier analysis revealed 1-, 2-, and 3-year success rates of 62%, 58%, and 53%, respectively. Three additional patients achieved success after undergoing a second TCR, and 1 patient achieved success after a third TCR. Postoperative complications included transient choroidal effusion (n=8), shallow anterior chamber requiring reformation (n=5), 5-fluorouracil-related corneal epitheliopathy (n=10), and bleb leak (n=1). Conclusions: TCR with adjunctive MMC is a safe and effective procedure following failure of a trabeculectomy. More than 1 revision may be necessary to achieve long-term IOP reduction.Keywords
This publication has 15 references indexed in Scilit:
- The Efficacy of 5-Fluorouracil Bleb Needling Performed 1 Year or More PosttrabeculectomyJournal of Glaucoma, 2009
- Needle Revision of Filtering BlebsJournal of Glaucoma, 2008
- Transconjunctival mitomycin-C in needle revisions of failing filtering blebsOphthalmology, 2003
- Antimetabolite Use in Revising Failing Filtering BlebsSeminars in Ophthalmology, 1999
- The treatment of encapsulated trabeculectomy blebs in an out-patient setting using a needling technique and subconjunctival 5-fluorouracil injectionEye, 1998
- Slit-lamp Needle Revision of Failed Filtering Blebs Using Mitomycin COphthalmology, 1996
- Needle Elevation of the Scleral Flap for Failing Filtration Blebs After Trabeculectomy With Mitomycin CAmerican Journal of Ophthalmology, 1996
- Needle Revision With and Without 5-Fluorouracil for the Treatment of Failed Filtering BlebsAmerican Journal of Ophthalmology, 1990
- Wound healing in glaucoma filtering surgerySurvey of Ophthalmology, 1987
- Conjunctival DialysisAmerican Journal of Ophthalmology, 1941